They suppress tumour growth via two mechanisms: firstly they may cause heat shock or oxidative stress, they may induce the expression of HSP110 and GRP170, which aids the restoration of protein folding and cellular function to counter proteotoxic stresses and thus promote cell survival; and secondly, HSP-peptide complexes presented on MHC class I and II molecules activate CD4+/CD8+ T-lymphocytes [112,117]. The gene discussed is CD4; the disease is neoplasm.