NFKB1 and cancer: Particularly, the NF-κB/Snail/YY1/RKIP loop, which is dysregulated in cancer, reveals that, while the overexpression of NF-κB and Snail causes YY1 activation, the eventual induction of RKIP expression downregulates its precursors: NF-κB, Snail and YY1 [24].