By means of the public available datasets of differential gene profiles established with large human cancer cohorts (http://gepia.cancer-pku.cn, accessed on 1 January 2018), we found that, out of 11 human cancers, GBM was among the top tumors displaying the greatest elevation in YKL-40 expression relative to the corresponding controls (Figure S1A). Here, CHI3L1 is linked to cancer.