MAP2K5 and neuroblastoma: It is known that ALK regulates the initiation of transcription of MYCN through the PI3K-AKT-MEK5-ERK5 signaling axis [55,56], and the stability of MYCN through PI3K-AKT-GSK3β signaling axis [57,58,59] in ALK-driven/MYCN-amplified NB.