Interestingly, CLB-GAR and CLB-GE cells are ALK-mutated with relatively low ALK expression levels while CLB-BAR and NB1 cells are ALK-amplified, expressing high levels of the ALK RTK (Figure 1B), indicating that ALK expression status might determine the sensitivity to IGF1R inhibition in ALK-driven NB cells. This evidence concerns the gene ALK and neuroblastoma.