Both adiponectin and T-cadherin are colocalized in tumor vasculature, for example, in the intratumoral capillaries of human hepatocellular carcinoma (HCC) and mammary tumors, which suggests that this receptor seems to be necessary for adiponectin-mediated signaling at the level of endothelial cells [36,54,230]. This evidence concerns the gene ADIPOQ and neoplasm.