In endometrial cancer cell lines, leptin promotes cell proliferation and invasion through the JAK2/STAT3, PI3K, ERK2 and COX2 pathways and regulates the expression of pro-angiogenic factors such as VEGF, IL-1β, HIF-1, leukemia inhibitory factor (LIF) and their respective receptors through the activation of JAK2-PI3K-ERK-mTOR [12,118]. Here, MAPK1 is linked to endometrial cancer.