VEGF is stimulated by HIF-1α and NFκB [6] and leptin, through the activation of HIF-1α and NF-kB via canonic (MAPK, PI-3K) and non-canonical (JNK, p38 MAP, PKC) signaling pathways, upregulates VEGF in breast cancer [196]. The gene discussed is VEGFA; the disease is breast carcinoma.