Non-HMW adiponectin (i.e., complexes with lower molecular weight) presents stronger anti-inflammatory effects, while the HMW form of adiponectin, whose active form constitutes nearly 70% of circulating adiponectin in healthy subjects, has the most noticeable role in improving insulin sensitivity and protecting against diabetes, resulting in different metabolic diseases in the case of impaired multimerization sensitivity [44,45]. This evidence concerns the gene ADIPOQ and diabetes mellitus.