Likewise, in breast cancer, Notch, IL-1 and Leptin Crosstalk Outcome (NILCO) are decisive for leptin upregulatory effects on cell proliferation and migration as well as VEGF/VEGFR-2 expression [222] but the level of NILCO biomarker expression depends on the presence of estrogen receptors [223]. The gene discussed is ESR1; the disease is breast cancer.