As noted, in A549 cell culture, a NSCLC model, transfection with adiponectin successfully increased the expression levels of MMP-1, MMP-2, MMP-9 and MMP-14, providing evidence of an adiponectin-MMPs-angiogenesis-involved mechanism in NSCLC invasion [93]. This evidence concerns the gene MMP2 and non-small cell lung carcinoma.