BTRC and Familial prostate cancer: A recent study demonstrated that β-TrCP upregulates the hypoxia-inducible factor 1α (HIF-1α) protein level and its transcriptional activity by competing with its binding to heat shock protein 70 (HSP70)/the carboxy terminus of HSP70-interacting protein (CHIP), antagonizing CHIP E3 ligase activity in prostate cancer [84].