BTRC and non-small cell lung carcinoma: Consistent with this, mammalian target of rapamycin complex 1 (mTORC1)/P70 ribosomal protein S6 kinase (P70S6K) inhibition induces proteasomal degradation of β-TrCP, which stabilizes programmed death-ligand 1 (PD-L1) in non-small-cell lung cancer (NSCLC) cells [67].