APEX1 and esophageal adenocarcinoma: The stability and activation of YAP1 are also regulated by apurinic/apyrimidinic endonuclease 1 (APE1), which binds to β-TrCP, possibly competing with the YAP1–β-TrCP interaction in response to acidic bile salt exposure in esophageal adenocarcinoma cells [195].