A computer analysis of data from HPV-negative HNSCC samples revealed that EGFR amplification and PI3KCA mutation (gene encoding p110α catalytic domain of PI3K) were found in more than half of the HNSCC cases, and the active status of the EGFR pathway can help to predict response to the PI3K inhibitor [105]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.