KIAA1671, although being poorly characterized, has been associated with cancer in several occasions: antibodies against KIAA1671 are found in breast cancer patient sera [97], KIAA1671 deletion was also found to be among the most common structural variants in organoids derived from intraductal papillary mucinous neoplasms [98], KIAA1671 has emerged as a gene associated with carotid paragangliomas [99] and KIAA1671 has lowered expression in PTC (papillary thyroid carcinoma) [100], a malignancy where EN1 and EN3 are reported. The gene discussed is EN1; the disease is differentiated thyroid carcinoma.