The EN2 variant interacts with components of several archetypal kinase signaling events: ERBB, insulin, JAK and BCR-ABL (chronic myeloid leukemia) based on KEGG enrichment analysis, which also share downstream signaling with ERK/ELK and PI3K/AKT signaling and also with JNK/AP-1 and STAT. This evidence concerns the gene JUN and chronic myelogenous leukemia, BCR-ABL1 positive.