Indeed, Reactome (Figure 3C) and KEGG (Supplementary Figure S2B) pathway analyses of interactors identified multiple terms consistent with involvement in various signaling pathways, including p53 in cancer, cell cycle (G2/M DNA replication checkpoint, activation of NIMA kinases and phosphorylation of Emi1) and ERBB2 signaling. The gene discussed is FBXO5; the disease is cancer.