The non-proliferation class can be further divided into two subclasses: the Wnt/β-catenin CTNNB1 subclass presents frequent CTNNB1 mutations and activation of the Wnt/β-catenin signaling pathway; and the interferon subclass is characterized by activation of the IL6–JAK–STAT signaling pathway and a more inflamed tumor microenvironment [2]. The gene discussed is CTNNB1; the disease is neoplasm.