Furthermore, other pathways such as hypoxia, WNT, TGF-β, and PI3K are reportedly linked to glioma radio-resistance by modulating the TP53 pathway [33,38,39,40], and their activities were also elevated in the cluster (Figure 4a), indicating an intertwined effect of these pathways on the BSG radiotherapy response. This evidence concerns the gene TP53 and glioma.