TNF and neoplasm: In contrast, we observed that the two immune-enriched clusters, “immune-enriched, fibrotic (IEF)” and “immune-enriched, non-fibrotic (IENF)”, showed relatively high activities in the pathways related to the anti-tumor immune response (TNF-α), tumor inflammation (NF-κB and JAK-STATs), and apoptosis (Trail), as compared with the other clusters, thus providing molecular clues for their better outcomes (Figure 4a).