RUNX3 and neoplasm: Notably, a systematic review and meta-analysis by Lu et al. on runt-related transcription factor 3 (RUNX3) methylation and hepatocellular carcinoma association in 491 HCC patients and 409 tumor-free controls (from 7 studies) found no sex association (OR: 1.30, 95% CI = 0.48–3.50) [28].