TP53 and gastric cancer: Notably, a study by Waraya et al., which examined DNA methylation aberrations along key p53 pathway genes (PGP9.5, NMDAR2B, CCNA1 and p53) in 163 primary gastric cancer samples, with higher methylation aberrations reported in males (Mann−Whitney p = 0.003; log rank RFS: p = 0.03, OS: p = 0.1) [22].