APC and colorectal cancer: Interestingly, a meta-analysis of 24 articles and 2025 total CRC patients by Liang et al. found no statistically significant association between APC methylation status and sex (M vs. F: OR 1.55, 95% CI 0.88–1.52, p = 0.31, I2 = 0%) in the early diagnosis of colorectal cancer, although this is just one of many epigenetic events that may drive tumorigenesis [14].