Another study by Rawłuszko et al. involving 52 CRC patients with paired normal tissue controls detected significantly lower amounts of 17β-Hydroxysteroid dehydrogenase type 1 (HSD17B1) gene transcript levels in male cancerous tissues compared to controls (transcript p = 0.0388; protein p = 0.2832), with no differences in gene versus protein levels in females (transcript p = 0.2340; protein p = 0.2119) [18]. Here, HSD17B1 is linked to colorectal carcinoma.