In mice xenografted with cervical tumors and treated with ATRA and PDL1 Ab, MDSCs were diminished and tumor growth decreased, presumably mediated by high intra-tumoral infiltration of CD4+ and CD107a+CD8+ cytotoxic T-cells and the production of pro-inflammatory cytokines (IFNγ, TNFα). The gene discussed is IFNG; the disease is neoplasm.