This was accompanied by the secretion of VEGFA, CSF1/M-CSF and MCP1 and the down-regulation of caspase-3, proposing an anti-apoptotic role for vitamin A derivatives, not only in allergic conditions but also in the tumor tissue microenvironment, implying a potential use for RAR agonists as immunomodulators. The gene discussed is CSF1; the disease is neoplasm.