MAPK8 and breast carcinoma: Membrane-associated-progestin-and-adipoQ-receptors (mPRs/PAQR5-9) [31] activate JNK1/2 and p38 MAPKs to elicit apoptosis in ovarian cancer cells, and progesterone receptor membrane component 1 (PGRMC1) augments breast cancer growth via transactivation of EGFR-PI3K-AKT signaling [32].