A prospective study [99] in patients with non-small-cell lung cancer who received docetaxel in combination with rocaltrol revealed that low serum vitamin correlated with high genomic expression of inhibitory immune checkpoints (PD1, TIGIT, TIM3), but low presence of the costimulatory CD28 molecule on CD8+ and Vγ9Vδ2+ T-cells. This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.