Nanoparticles loaded with obeticholic acid were enriched in liver sinusoidal endothelial cells and Kupffer cells and attenuated tumor growth in an orthotopic mouse model [185], accompanied by increased secretion of CXCL16 and IFNγ and expansion of natural killer T (NKT) cell populations within the tumor. The gene discussed is CXCL16; the disease is neoplasm.