BWS and SRS cases that are linked to the IGF2-H19 locus are caused by increased or decreased expression of the growth-regulating IGF2 gene, respectively, and concordant changes in H19 expression may contribute to the clinical aetiology of these disorders as well, through the trans effects of this conserved lncRNA (see also below). The gene discussed is IGF2; the disease is Beckwith-Wiedemann syndrome.