IRF1 and dysplasia: Moreover, the positive ratio of the representative immune checkpoint protein PD-L1 to the representative HLA-I inducible factor interferon regulatory factor-1 (IRF-1) in dysplasia/CC (PD-L1: 100%, 18/18, and IRF-1: 100%, 18/18, respectively) was higher than that in SCRC without HLA-I expression (PD-L1: 35.3%, 6/17, and IRF-1: 41.2%, 7/17, respectively).