NRIP1 and infection: TMV p50 interacts indirectly with toll-like/interleukin-1 receptor-type domain protein encoded by the N gene; in the Nicotiana benthamiana, such signaling requires an additional chloroplastic rhodanese sulfurtransferase, NRIP1 (Nuclear Receptor Interacting Protein 1), that recognizes p50 and inhibits the development of infection [18].