SOX2 and cancer: To evaluate the presence and distribution of LVs within mouse skin lesions, we conducted IFM analyses, utilizing markers for LVs (LYVE-1, lymph vessel endothelial hyaluronan receptor 1) [38], cancer stem cells (CSCs) (SOX2, nuclear SRY-Box Transcription Factor 2) [39,40], and basal progenitor keratinocytes (K5, Keratin 5) [41], which, in the context of skin carcinomas, showcase uncontrolled growth, extending into suprabasal layers.