Herein, we evaluated for the first time the anticancer efficacy of TPyP-C1, Zn-TPyP-C1, TPyP-C2, Zn-TPyP-C2, Co-TpPyP-C2, Por-C3, and Mg-Por-C3 in human prostate cancer cell lines. This evidence concerns the gene AQP1 and prostate carcinoma.