We utilized pentaplex panel testing for 23 lung carcinomas, 23 sarcomas, 4 thyroid carcinomas, 3 salivary gland tumors, and 3 pancreatic carcinomas with oncogenic gene translocations (ALK: 31; ROS1 10; RET: 9; NTRK1: 2; NTRK3: 4). The gene discussed is ROS1; the disease is lung carcinoma.