CRP and systemic lupus erythematosus: As ESR, Anti-dsDNA Ab, CRP and LDH were increased in SLE patients both in our study and others, and these clinical parameters may also be indicated as biomarkers in SLE identification and severity [20,21,22,23], we also performed ROC analysis for ESR, Anti-dsDNA Ab, CRP, IgG and LDH so as to better compare the efficacy of Metrnβ with these markers.