In addition, SLE is characterized by the breakdown of immunological tolerance and homeostasis, in which regulatory T cells (Treg) as well as IL-10 producing B cells (B10) have been described as key regulators while deficit [15,16,17].We therefore compared the relationship of Metrnβ with these regulatory immune cells in SLE in order to further demonstrate the regulatory role of Metrnβ in SLE. This evidence concerns the gene IL10 and systemic lupus erythematosus.