CDKN2A and hepatocellular carcinoma: In 2011, Park et al. examined the effects of liver-specific Foxm1b expression in mice lacking Arf and found that dysregulated Foxm1b expression in Arf+/− and Arf−/− settings, but not in Arf+/+ wild-type mice, promoted the metastasis of hepatocellular carcinoma (HCC) [44].