In addition to loss of NF1 and INK4a/ARF, other key players in MPNST include the globally important tumor suppressor, p53, and two epigenetic regulators in the polycomb repressive complex 2 (PRC2), EED and SUZ12, all of which are lost in MPNSTs [16,27,28]. Here, NF1 is linked to malignant peripheral nerve sheath tumor.