NFKB1 and COVID-19: In addition, 15d-PGJ2, as an electrophilic molecule, forms adducts with proteins, changing their structure and functions, which allows them, for example, to modify both the inflammatory process (NFκB pathway) [52] and the antioxidant response (via Nrf2 signaling) [53] in the granulocytes of patients who died from COVID-19, as observed in this study.