The common pathologies of sAD and fAD include neurofibrillary tangles (NFTs) formed by excessive phosphorylated Tau (p-Tau) in the cortex and subcortex, the extracellular deposition of β-amyloid (Aβ) forming amyloid plaques, neuronal loss, and brain atrophy [3]. Here, MAPT is linked to familial Alzheimer disease.