In addition, in vivo imaging of APP/PS1 mice aged 2–3 months using curcumin detected Aβ plaques in mouse retinas (mainly in the GCL and NFL), which was earlier than that in hippocampus and brain tissues [16], suggesting that the detection of Aβ deposition in the retina may be of great significance for the early diagnosis of AD. Here, APP is linked to Alzheimer disease.