The data demonstrated the increased expression of the primary angiogenic markers, CD31, ANG2, VEGF, and MMP9, and a decrease in vWF, NOTCH (1–4), and DELTA-4 in HUVECs treated with lipedema adipocyte-CM as compared to the control untreated HUVECs in the 2D monolayer culture. This evidence concerns the gene VWF and Lipedema.