Several studies have demonstrated an increase in the levels of angiogenic and inflammatory cytokines and chemokines in the serum of lipedema patients, including VEGFA and VEGFC, transforming growth factor (TGFα and β1), interleukin 8 (IL-8), chemokines C-X-C motif chemokine (CXCL3 and 11), and monocyte-chemotactic protein (MCP-1 and -3) [26,27,28,29]. This evidence concerns the gene VEGFA and Lipedema.