Our data show an upregulation in the gene expression of VEGF (A–D), VEGFR1 (FLT1), VEGFR2 (KDR), FGF (1–2), and HGF in HUVECs treated with CM from lipedema adipocyte as compared to untreated and HUVECs treated with CM from healthy adipocytes and ASCs, suggesting that the CM of lipedema adipocytes promote angiogenesis in HUVECs. This evidence concerns the gene KDR and Lipedema.