BCAR4 and osteosarcoma: Xing et al. showed that the therapeutic delivery of antisense locked nucleic acids (LNAs) specific to lncRNA Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) (Accession No: NONHSAG018621.2 (NONCODE)) effectively suppresses metastasis in a breast cancer mouse model using locked nucleic acids (LNAs) targeting the lncRNA BCAR4 and the knockdown of BCAR4 by siRNA, inhibiting osteosarcoma tumorigenesis and lung metastasis in vivo [247], Moreover, Tian et al. recently showed the inhibition of the malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo [248].