Neurodegenerative disorders are characterized by fundamental processes associated with progressive neuronal dysfunction and death, and are typically attributed to accumulations of specific proteins, which are localized in β-amyloid-containing formations in the case of AD, α-synuclein in Parkinson’s Disease and various ubiquitinated proteins, like TDP-43, in Amyotrophic Lateral Sclerosis [40]. Here, TARDBP is linked to Alzheimer disease.