RN decreases the oxidative stress involved in multiple myocardial mechanical dysfunctions and different types of arrhythmias, either by modulating the formation of reactive oxygen species (ROS) [17,58] or by facilitating the function of different superoxide dismutase enzymes (MnSOD and Cu/ZnSOD) [59,60]. The gene discussed is SOD2; the disease is Arrhythmia.