CHD7 and CHARGE syndrome: Human chromatin remodeling factor CHD7, which encodes an ATP-dependent chromatin helicase DNA-binding protein, CHD7, a member of the SNF2-protein superfamily, is the gene known to be associated to CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia choanae, Retardation of growth and/or development, Genital abnormalities, and Ear abnormalities) [1,2,3].