FAT1 and acute respiratory distress syndrome: Mice expressing the fat-1 gene and therefore endogenously synthesizing n-3 PUFAs, or mice receiving a fish oil infusion, demonstrated reduced leukocyte invasion, protein leakage, and decreased levels of several pro-inflammatory chemokines and cytokines in the lung tissue during LPS-induced ARDS when compared to solvent-treated or wild-type (WT) ARDS controls [38,39].