TGF-β, as a well-known cytokine related to immune regulation, is widely expressed in renal tissues and involved in a variety of DKD characteristics such as extracellular matrix deposition, renal fibrosis, glomerular basement membrane expansion, and TGF-β pathway appeared as DCP when the DDCs of EnC and B cells acted as the source [15]. This evidence concerns the gene TGFB1 and renal fibrosis.