In the current study, we have alternately provided evidence suggesting that B cells, except T cells, may also be driven by mitochondria and participate in the process of DKD with Cd74 in the APP pathway (Figure 7A,B) and its interaction with other renal cells through MHC-II, TGF-β, in the SELL pathway (Table 2 and Figure S7). This evidence concerns the gene APP and diabetic kidney disease.