GAST and neoplasm: Thus, gastric hypoacidity stimulates gastrin release, which stimulates the release of signal substances including histamine and Reg protein [121] from the ECL cell, which, at the same time, is stimulated to divide, thereby increasing the risk of neoplasia (NETs and carcinomas of diffuse type), whereas the signal substances from the ECL cell stimulate the stem cell towards proliferation and neoplasia [123].