Further mechanistic exploration revealed HFD triggered PBDE47-induced dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome gene 1 (DAX-1) expression and lowered steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) levels in rat testicular interstitials [199]. Here, STAR is linked to chronic primary adrenal insufficiency.