In contrast, type 1, 1.4-Mb deletions of the NF1 gene are associated with increased number and earlier appearance of cutaneous and plexiform neurofibromas, a higher risk of developing malignant peripheral nerve sheath tumours, severe cognitive abnormalities, increased cardiovascular anomalies, a recurrent pattern of dysmorphic facial features and other signs of overgrowth including tall stature, large hands and feet [37]. This evidence concerns the gene NF1 and cancer.