Seven miRNAs (miR-9-5p, miR-29a-3p, miR-106a-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-5p) were located in the upstream genomic regions of the AD related genes, APP, PSEN1, PSEN2, and BACE1 [93], providing insight into miRNAs as biomarkers, while also linking them to genes implicated in AD. The gene discussed is PSEN1; the disease is Alzheimer disease.