In addition, the downregulation of ciRS-7 and its “sponging” effects on miRNA-7 induce an increase of miR-7 levels [129], leading to the downregulation of AD-associated targets, such as ubiquitin protein ligase, UBE2A, an essential enzyme in the process of amyloid clearance in AD brain [130]. This evidence concerns the gene UBE2A and Alzheimer disease.