This suggests a dual effect of PF-562271 on inhibiting Pyk2/FAK in glioma cells—first, through the direct inhibition of Pyk2/FAK within glioma cells and second, through the reduction of TIM infiltration—consequently, attenuating the cytokine-related activation of Pyk2/FAK within glioma cells. The gene discussed is PTK2; the disease is glioma.