TLR4 and Sepsis: For example, Chen et al. reported in their research that miR-let-7b could regulate immunosuppression by targeting the neutrophilic TLR4/NF-κB signal during CLP-induced sepsis, which reveals novel mechanisms of the involvement of miR-let-7b in neutrophilic inflammatory activity and provides valuable therapeutic targets for severe inflammation-driven diseases, including sepsis and the current COVID-19 [205].