The results of this study show reduced levels of serum Klotho in T2DM patients when compared to a group of non-T2DM subjects with similar age, sex distribution, BMI and comorbidities—including CAD—as well as preserved kidney function (eGFR ≥ 60 mL/min/1.73 m2) and normal albuminuria (ACR < 30mg/g). Here, KL is linked to coronary artery disorder.