APOE and hyperlipidemia: In this work, we have used the ApoE−/− mice that develop severe hyperlipidemia due to an accumulation of chylomicrons and Very-Low-Density Lipoprotein (VLDL) and lipoprotein glomerulopathy, making this a model of hyperlipidemic renal injury [19] to study the impact of sex on lesion development.