RPTOR and hypertensive disorder: Of interest, rapamycin, which promotes autophagy by inhibiting mTOR [43], has been shown to alleviate hypertension in Dahl salt-sensitive rats [44], and deletion of raptor, which functions downstream of mTOR and inhibits autophagy, causes a Bartter’s syndrome/furosemide-like renal phenotype including massive polyuria and hypercalciuria [45].