On the contrary, in MRC5 exposed to CM from MDA-MB-231 treated with SR or CBD, many of these factors were significantly reduced compared to untreated CM-MDA, including TGFβ, TGFβ2, IGFI, PDGF-AB, and FGFs (Figure S4C,D), enforcing the observation that the treatment of MDA-MB-231 with SR and CBD prevents the activation of normal fibroblasts in the tumor microenvironment. The gene discussed is IGF1; the disease is neoplasm.