In particular, in MDA-MB-231 and MRC5 cells, SR and CBD affect the secretion of growth factors involved in proliferation and angiogenesis (bFGF, FGF4, -6, -7, VEGF-D, PIGF, PDGF-AB, and -BB), tumor metabolism (IGFII, IGBPs), and immune response (GCSF, MCSF, TGF family members) (Figures S3A,B and S4A,B). Here, IGF2 is linked to neoplasm.