PPARGC1B and obesity due to melanocortin 4 receptor deficiency: In experiments in obese mice, miR-378 is designated as an inhibitor of insulin signaling, by inhibiting p110a, regulator of glucose and fatty acid metabolism, by counteracting peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1β) [16] and is potentially associated with the development of insulin resistance (IR), while other studies have demonstrated its association with activation of adipogenesis of BAT and protection from diet-induced obesity [17,18].