NFKB1 and colonic neoplasm: Since our previous studies indicated that a number of genes induced by L1 overexpression in colon cancer cells involve the NF-κB pathway [34,35], we have also examined the expression of Mucin2 under conditions when this pathway was inhibited by the expression of shRNA against the p65 subunit of NF-κB (shp65) and in cells where the pathway was blocked using the IκB-SR (Figure 7F).