CLU and cancer: In addition, increasing evidence has demonstrated that CLU modulates a variety of cellular events associated with cancers, such as cancer stemness, epithelial–mesenchymal transition, cell survival, and treatment resistance, thus mediating the progression of many cancers, including breast carcinoma, renal cell carcinoma, bladder cancer, prostate cancer, hepatocellular carcinoma, esophageal cancer, colorectal cancer, ovarian cancer, and lung cancer [8,12,13,14,15,16].