PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Genome-wide association studies (GWAS) have identified several genetic variants that are associated with MASLD susceptibility, including single-nucleotide polymorphisms (SNP) in PNPLA3 (rs738409 C>G p.Ie148Met; patatin-like phospholipase-domain-containing protein 3), MBOAT7 (rs62641738 C>T; membrane-bound O-acyltransferase-domain-containing 7), and GCKR (rs780094 C>T; glucokinase regulator) [5].