LncRNA BDNF-AS induced endocrine resistance and malignant progression of BC, and it promoted ribonuclease/angiogenin inhibitor 1 (RNH1) protein degradation via tripartite motif containing 21 (TRIM21) and abolished RNH1-dependent mTOR mRNA decay, activating mTOR signaling [47]. This evidence concerns the gene BDNF and breast cancer.