GPCRs activated by fatty acid-derived lipids can control glucose homeostasis by affecting insulin and incretin secretion and are considered potential targets for the treatment of diabetes, including free fatty acid receptor 1 (FFA1/GPR40), FFA4 (GPR120), and lipid metabolite-binding glucose-dependent insulinotropic receptor (GPR119) [31]. The gene discussed is INS; the disease is diabetes mellitus.