GIP receptor agonists are not used as single-target drugs to treat patients with diabetes, because after GIPR is activated, in addition to the lipogenic effect of insulin, GIP can recruit chylomicrons, enhance the activity of lipoprotein lipase, promote the hydrolysis of dietary triglycerides and the release of free fatty acids, and promote lipid storage, thus leading to obesity [7]. The gene discussed is INS; the disease is Obesity.