CYP3A4 and lung adenocarcinoma: For the paclitaxel-metabolizing CYPs, deletion of CYP2C8, but not of CYP3A4 was detected in primary lung tumour and in lung and liver metastases (the average copy number of CYP2C8 in primary lung adenocarcinoma: 1.60, in lung metastasis: 1.47, in liver metastasis: 1.08).