Relative copy number calculation indicated an increase in two genes, F5 and RPPH1, and a decrease in CYP2C8 in the primary tumour sample (the mean of the relative copy number for F5: 1.297, for RPPH1: 1.301 and for CYP2C8: 0.80), whereas in lung and liver metastases, both an increase and a decrease in relative copy numbers of several genes were detected (lung metastasis sample: F5: 1.514, BCKDHA: 1.681, ALB: 0.653, CYP2C8: 0.713; liver metastasis: F5: 2.289, RPPH1: 1.882, BCKDHA: 1.343, CD36: 1.295, ALB: 0.616, CYP2C8: 0.583) (Figure 1a–c). Here, CYP2C8 is linked to neoplasm.