In the primary tumour samples from non-responder patients (N = 9), copy number alterations in CYP2C8 and/or CYP3A4 were detected more frequently than in the samples from responders (N = 8) (non-responders 6/9 vs. responders 1/8, p = 0.0498, Fisher’s exact test) (Figure 2). Here, CYP3A4 is linked to neoplasm.