CYP2C8 and neoplasm: The chromosomal location of the CYP2C8 gene (chr 10q23.33) is close to tumour suppressor genes, such as PTEN (phosphatase and tensin homolog, chr 10q23.31), being involved in cell cycle regulation and CPEB3 (cytoplasmic polyadenylation element binding protein 3, chr 10q23.32), the regulator of EGFR transcription [47].