An analysis of all of the possible phenotypic combinations of the VDR genotype and the HLA DRB1*15.01 allele in a cohort of MS patients and healthy controls showed that the co-presence of VDR TaqI (TT) in subjects carrying the risk factor HLA DRB1*15.01 (i.e., DRB1*15.01 positive) was indeed significantly more frequent in healthy subjects compared with MS patients, suggesting that the VDR TaqI (TT) genotype may exert a protective role for MS [11]. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.