Based on the results of the in vivo COVID-19 cytokine storm study [7,15,16,17], we focused on the IL-1β, IL-2, IL-6, TNFα, IL-4, and IL-10 molecular pathways as the key elements of the inflammatory response in order to identify the molecular mechanisms of peptidergic regulation of the cytokine storm in COVID-19. The gene discussed is TNF; the disease is COVID-19.