The antigen-recognition patterns of MOGAD might differ from those of anti-aquaporin 4 (AQP4) autoantibody-related neuromyelitis optica spectrum disorders (NMOSDs) and anti-NMDAR autoantibody-related autoimmune encephalitis, two clinical presentations with well-characterized antibody-binding sites on the disease-related antigen [13,14]. The gene discussed is AQP4; the disease is autoimmune encephalitis.