The significant fractional increase in β-sheet secondary structure observed for the AD cell culture as compared to the control one (from 38.2 to 71.2%; cf. Figure 10b) is in agreement with the high-resolution cryo-electron microscopy observations reported by Fitzpatrick et al. [187] on Tau filaments extracted from AD human cerebral cortex. The gene discussed is MAPT; the disease is Alzheimer disease.